Objectives

The primary objectives of the Action include the identification at the cellular level, of the proteins involved in Fe/S cluster assembly followed by the molecular, biochemical and structural characterization of these proteins and their complexes. Thoroughly description of the electronic and structural properties of the Fe/S clusters transiently bound to protein complexes will be carried out by applying several biophysical methods such as Mass Spectroscopy, Nuclear Magnetic Resonance, Electron Paramagnetic Resonance, Mossbauer. Among the main objectives is the investigation of the signaling pathways linking Fe/S protein biogenesis pathways to cellular iron homeostasis, as well with the ultimate goal of unravelling pathophysiological mechanisms in human diseases, which are related to the investigated processes.

The Action intend to create a network for enhancing the current understanding of cellular Fe/S protein biogenesis by bringing together leading scientists from complementary fields, each contributing with its specific expertise and resources towards common goals. All participants are involved into National and International PhD programs that attract strudents from many European and non-European countries. This Action will provide to young researchers the opportunity to expand their competences, have a close-up view on other fields of activity, explore the European dimension of the academic and non-academic research in chemistry and life science, being exposed to transnational and trans-sectoral research and/or working environments.