Synthesis and assembly of iron-sulphur (Fe/S) clusters into target proteins is a highly complex, coordinated and conserved process in living cells. Several machineries in both bacteria and eukaryotes have been discovered to assist Fe/S protein maturation. The importance of Fe/S proteins for human life and the comprehension at the molecular and cellular level of their biogenesis is documented by an increasing number of diseases linked to functional impairment of these proteins and of their maturation processes. Many of these diseases are fatal, sometimes in early childhood, which is not surprising based on the essential needs of Fe/S proteins in cellular metabolism. The founding member of Fe/S diseases is the neurodegenerative disorder Friedreich’s ataxia, in which the protein Frataxin is functionally deficient, either by a more than 70% decrease in protein levels as a result of decreased transcription or by point mutations. This functional impairment is associated with decreased activities of respiratory complexes I–III and of mitochondrial Aconitase


Prof. Prem Ponka (left) with the Presidential Prize for Life Achievements  and  Prof. Roland Lill (right) with the 2019 Paul Ehrlich Prize awarded by the International Society for the Study of Iron in Biology and Medicine for his contribution to the understanding of Iron-Sulfur protein biogenesis (Prize was awarded at the 2019 Bioiron Conference, ACT-EMBL Heidelberg, May 5-9, 2019)

The FesBioNet consortium wish to congratulate its member, Prof, Dr.Roland Lill for his award, The 2019 Paul Ehrlich Prize, for hisachievements in the understanding of ISP Biogenesis.

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Mario Piccioli
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CIRMMP- Consorzio Interuniversitario Risonanze Magnetiche di MetalloProteine
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