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The Biogenesis of Iron-sulfur Proteins: from Cellular Biology to Molecular Aspects

The main aim and objective of the Action is to address iron-sulfur (Fe/S) protein biogenesis in living systems and to investigate molecular mechanisms underlying human diseases related to Fe/S protein biogenesis dysfunctions. The Action will provide a molecular view of Fe/S proteins assembly processes and trafficking pathways at a systemic level, including their connections with cellular iron homeostasis processes.

 

 

Areas of expertise

Areas of Expertise relevant for the Action in the field of Biological Sciences: Systems Biology,General Biochemistry and Metabolism, Structural Biology (NMR, Crystallography, EM), Molecular biology and interactions, Biochemistry

Challenge

Iron-sulfur proteins represent one of the most extensively studied families of proteins. A growing interest in the field over the last decade has been observed; however, an integrated approach which provides a unified picture at system level is still missing. An inter- and multi-disciplinary background is therefore needed for the generation and training of creative, entrepreneurial and innovative scientists successfully engaged in the challenges of the modern research directed to impact in human health

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State-of-the-art

The past decade has led to the discovery of novel Fe/S proteins and insights into how their Fe/S cofactors are formed and incorporated into apoproteins.

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Aim of the Action

The Aim of the Action is to define a network able to coordinate and integrate intersectorial disciplines in Fe/S protein biogenesis. 

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Network

The challenge of this Action can be reached uniquely in the context of a pan European framework 

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Close

The Aim of the Action is to define a network able to coordinate and integrate intersectorial disciplines in Fe/S protein biogenesis. 

The major research methodologies used in this Action come from various scientific fields: genetic and molecular cell biology, protein expression and purification approaches, structure and dynamics characterization of the proteins, metalloproteomics methods and spectroscopic techniques. Some of the most pressing problems to be solved in future research of Fe/S proteins biogenesis, which will be addressed by the Action are listed below:

  • Elucidation of the molecular mechanisms of de novo Fe/S cluster assembly in living cells
  • Isolation and chemical characterization of the substrated exported from mitochondria to assist extra-mitochondrial Fe/S-protein biogenesis
  • Development of therapeutic strategies in the treatment of Fe/S diseases

COST meeting at Trest Castle, Czech Republic (Oct 2017)

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Upcoming Events with Potential Interest to FeSBioNet

Iron-Sulfur Proteins–Biogenesis, Regulation and Roles in Health and Disease

39th Steenbock Symposium - Memorial Union

May 29, 2018 to Jun 02, 2018
web-site: https://biochem.wisc.edu/symposia/steenbock/39th

The European Iron Club 2018 Meeting

February 8 - 11, 2018
ETH Zürich, Main Building
Zürich, Switzerland
web-site: http://www.ironclub2018.ethz.ch/

 

Contact Information

Scientific Representative
Mario Piccioli
+390554575265
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Administrative Representative
Francesca Di Gloria
+390554574294
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Scientific Officer
Lucia Forzi
COST Association
Avenue Louise 149 1050 Brussels | Belgium

Administrative Officer
Svetlana Voinova
COST Association
Avenue Louise 149 1050 Brussels | Belgium

Mailing Address

CIRMMP- Consorzio Interuniversitario Risonanze Magnetiche di MetalloProteine
CERM- University of Florence
Via L. Sacconi 2
50019 Sesto Fiorentino, Florence
Italy