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The Biogenesis of Iron-sulfur Proteins: from Cellular Biology to Molecular Aspects

The main aim and objective of the Action is to address iron-sulfur (Fe/S) protein biogenesis in living systems and to investigate molecular mechanisms underlying human diseases related to Fe/S protein biogenesis dysfunctions. The Action will provide a molecular view of Fe/S proteins assembly processes and trafficking pathways at a systemic level, including their connections with cellular iron homeostasis processes.

 

 

Areas of expertise

Areas of Expertise relevant for the Action in the field of Biological Sciences: Systems Biology,General Biochemistry and Metabolism, Structural Biology (NMR, Crystallography, EM), Molecular biology and interactions, Biochemistry

Challenge

Iron-sulfur proteins represent one of the most extensively studied families of proteins. A growing interest in the field over the last decade has been observed; however, an integrated approach which provides a unified picture at system level is still missing. An inter- and multi-disciplinary background is therefore needed for the generation and training of creative, entrepreneurial and innovative scientists successfully engaged in the challenges of the modern research directed to impact in human health

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State-of-the-art

The past decade has led to the discovery of novel Fe/S proteins and insights into how their Fe/S cofactors are formed and incorporated into apoproteins.

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Aim of the Action

The Aim of the Action is to define a network able to coordinate and integrate intersectorial disciplines in Fe/S protein biogenesis. 

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Network

The challenge of this Action can be reached uniquely in the context of a pan European framework 

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Close

The past decade has led to the discovery of novel Fe/S proteins and insights into how their Fe/S cofactors are formed and incorporated into apoproteins. 

These studies aim to the definition of the molecular mechanisms of the biogenesis of Fe/S proteins in eukaryotic cells in order to derive advance knowledge on the cause of diseases or disease phenotypes associated with defects in these Fe/S proteins, and therefore new therapeutic approaches can be envisaged on the basis of the acquired information. However, despite the impressive progress in research on Fe/S protein biogenesis during the last decade, exciting years of further exploration are ahead of us, ranging from basic structural, biochemical and cell-biological research to physiology and molecular medicine.

COST meeting at Patras, Greece (Sept 2016)

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Contact Information

Scientific Representative
Mario Piccioli
+390554575265
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Administrative Representative
Francesca Di Gloria
+390554574294
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Scientific Officer
Lucia Forzi
COST Association
Avenue Louise 149 1050 Brussels | Belgium

Administrative Officer
Svetlana Voinova
COST Association
Avenue Louise 149 1050 Brussels | Belgium

Mailing Address

CIRMMP- Consorzio Interuniversitario Risonanze Magnetiche di MetalloProteine
CERM- University of Florence
Via L. Sacconi 2
50019 Sesto Fiorentino, Florence
Italy