State-fo-the-art

The past decade has led to the discovery of novel Fe/S proteins and insights into how their Fe/S cofactors are formed and incorporated into apoproteins. 

These studies aim to the definition of the molecular mechanisms of the biogenesis of Fe/S proteins in eukaryotic cells in order to derive advance knowledge on the cause of diseases or disease phenotypes associated with defects in these Fe/S proteins, and therefore new therapeutic approaches can be envisaged on the basis of the acquired information. However, despite the impressive progress in research on Fe/S protein biogenesis during the last decade, exciting years of further exploration are ahead of us, ranging from basic structural, biochemical and cell-biological research to physiology and molecular medicine.